Cardiac pacemaker channel (HCN4) inhibition and atrial arrhythmogenesis after releasing cardiac sympathetic activation

Clinical trials and studies with ivabradine implicate cardiac pacemaker channels (HCN4) in the pathogenesis of atrial arrhythmias. Because acute changes in cardiac autonomic tone predispose to atrial arrhythmias, we studied humans in whom profound cardiac sympathetic activation was rapidly relieved...

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Publicado en:Sci Rep
Autores principales: Chobanyan-Jürgens, Kristine, Heusser, Karsten, Duncker, David, Veltmann, Christian, May, Marcus, Mehling, Heidrun, Luft, Friedrich C., Schröder, Christoph, Jordan, Jens, Tank, Jens
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5958126/
https://ncbi.nlm.nih.gov/pubmed/29773827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26099-9
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