Targeting UDP-α-D-glucose 6-dehydrogenase inhibits glioblastoma growth and migration

UDP-Glucose 6-dehydrogenase (UGDH) produces UDP-α-D-glucuronic acid, the precursors for glycosaminoglycans (GAGs) and proteoglycans (PGs) of the extracellular matrix. Elevated GAG formation has been implicated in a variety of human diseases, including glioblastoma (GBM). In our previous study, we fo...

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Pubblicato in:Oncogene
Autori principali: Oyinlade, Olutobi, Wei, Shuang, Lal, Bachchu, Laterra, John, Zhu, Heng, Goodwin, C. Rory, Wang, Shuyan, Ma, Ding, Wan, Jun, Xia, Shuli
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5957772/
https://ncbi.nlm.nih.gov/pubmed/29479058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0138-y
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