A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function

Drug-induced liver injury (DILI) is a leading cause of acute liver failure and transplantation. DILI can be the result of impaired hepatobiliary transporters, with altered bile formation, flow, and subsequent cholestasis. We used gadoxetate dynamic contrast-enhanced magnetic resonance imaging (DCE-M...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Karageorgis, Anastassia, Lenhard, Stephen C., Yerby, Brittany, Forsgren, Mikael F., Liachenko, Serguei, Johansson, Edvin, Pilling, Mark A., Peterson, Richard A., Yang, Xi, Williams, Dominic P., Ungersma, Sharon E., Morgan, Ryan E., Brouwer, Kim L. R., Jucker, Beat M., Hockings, Paul D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5957399/
https://ncbi.nlm.nih.gov/pubmed/29771932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197213
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