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The rational design, synthesis and antimicrobial properties of thiophene derivatives that inhibit bacterial histidine kinases
The emergence of multi-drug-resistant bacteria emphasizes the urgent need for novel antibacterial compounds targeting unique cellular processes. Two-component signal transduction systems (TCSs) are commonly used by bacteria to couple environmental stimuli to adaptive responses, are absent in mammals...
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| Udgivet i: | J Med Chem |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5957078/ https://ncbi.nlm.nih.gov/pubmed/27575438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00580 |
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