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The rational design, synthesis and antimicrobial properties of thiophene derivatives that inhibit bacterial histidine kinases

The emergence of multi-drug-resistant bacteria emphasizes the urgent need for novel antibacterial compounds targeting unique cellular processes. Two-component signal transduction systems (TCSs) are commonly used by bacteria to couple environmental stimuli to adaptive responses, are absent in mammals...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Boibessot, Thibaut, Zschiedrich, Christopher P., Lebeau, Alexandre, Bénimèlis, David, Dunyach-Rémy, Catherine, Lavigne, Jean-Philippe, Szurmant, Hendrik, Benfodda, Zohra, Meffre, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5957078/
https://ncbi.nlm.nih.gov/pubmed/27575438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00580
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