Functional effects of TrkA inhibition on system x(C)(−)-mediated glutamate release and cancer-induced bone pain

Breast cancer cells release the signalling molecule glutamate via the system x(C)(−) antiporter, which is upregulated to exchange extracellular cystine for intracellular glutamate to protect against oxidative stress. Here, we demonstrate that this antiporter is functionally influenced by the actions...

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Bibliographic Details
Published in:Mol Pain
Main Authors: Miladinovic, Tanya, Ungard, Robert G, Linher-Melville, Katja, Popovic, Snezana, Singh, Gurmit
Format: Artigo
Language:Inglês
Published: SAGE Publications 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5956640/
https://ncbi.nlm.nih.gov/pubmed/29761734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806918776467
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