Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis

BACKGROUND: Calcific atherosclerosis is a major challenge to intraluminal drug delivery in peripheral artery disease (PAD). OBJECTIVES: We evaluated the effects of orbital atherectomy on intraluminal paclitaxel delivery to human peripheral arteries with substantial calcified plaque. METHODS: Diagnos...

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發表在:J Control Release
Main Authors: Tzafriri, Abraham R., Garcia-Polite, Fernando, Zani, Brett, Stanley, James, Muraj, Benny, Knutson, Jennifer, Kohler, Robert, Markham, Peter, Nikanorov, Alexander, Edelman, Elazer R.
格式: Artigo
語言:Inglês
出版: 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955709/
https://ncbi.nlm.nih.gov/pubmed/28867375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2017.08.037
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