Multi-stage differentiation defines melanoma subtypes with differential vulnerability to drug-induced iron-dependent oxidative stress

Malignant transformation can result in melanoma cells that resemble different stages of their embryonic development. Our gene expression analysis of human melanoma cell lines and patient tumors revealed that melanoma follows a two-dimensional differentiation trajectory that can be sub-classified int...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Tsoi, Jennifer, Robert, Lidia, Paraiso, Kim, Galvan, Carlos, Sheu, Katherine M., Lay, Johnson, Wong, Deborah J.L., Atefi, Mohammad, Shirazi, Roksana, Wang, Xiaoyan, Braas, Daniel, Grasso, Catherine S., Palaskas, Nicolaos, Ribas, Antoni, Graeber, Thomas G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5953834/
https://ncbi.nlm.nih.gov/pubmed/29657129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.03.017
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