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The PER2 enhancer nobiletin as novel therapy in murine models of circadian disruption resembling delirium

OBJECTIVES: Delirium occurs in approximately 30% of critically-ill patients, and the risk of dying during admission doubles in those patients. Molecular mechanisms causing delirium are largely unknown. However, critical illness and the intensive care unit environment consistently disrupt circadian r...

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Bibliografske podrobnosti
izdano v:Crit Care Med
Main Authors: Gile, Jennifer, Scott, Benjamin, Eckle, Tobias
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5953804/
https://ncbi.nlm.nih.gov/pubmed/29489460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000003077
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