14-3-3z sequesters cytosolic T-bet, up-regulating IL-13 in Tc2 and scleroderma CD8+ lymphocytes

BACKGROUND: Interleukin(IL)-13-producing CD8+ T cells have been implicated in the pathogenesis of type-2 driven inflammatory human conditions. We have shown that CD8+IL-13+ cells play a critical role in cutaneous fibrosis, the most characteristic feature of systemic sclerosis (scleroderma; SSc). How...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Cascio, Sandra, Medsger, Thomas A., Hawse, William F., Watkins, Simon C., Milcarek, Christine, Moreland, Larry W., Lafyatis, Robert A., Fuschiotti, Patrizia
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5953767/
https://ncbi.nlm.nih.gov/pubmed/29155097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2017.10.029
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