Impact of carbonylation on glutathione peroxidase-1 activity in human hyperglycemic endothelial cells

AIMS: High levels of glucose and reactive carbonyl intermediates of its degradation pathway such as methylglyoxal (MG) may contribute to diabetic complications partly via increased generation of reactive oxygen species (ROS). This study focused on glutathione peroxidase-1 (GPx1) expression and the i...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Sultan, Cheryl S., Saackel, Andrea, Stank, Antonia, Fleming, Thomas, Fedorova, Maria, Hoffmann, Ralf, Wade, Rebecca C., Hecker, Markus, Wagner, Andreas H.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5952877/
https://ncbi.nlm.nih.gov/pubmed/29499564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.02.018
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