Metformin attenuates triglyceride accumulation in HepG2 cells through decreasing stearyl-coenzyme A desaturase 1 expression

BACKGROUND: The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased worldwide. Metformin decreases triglyceride (TG) accumulation in hepatocytes in vivo and in vitro. Stearyl-coenzyme A desaturase 1 (SCD1) knockout mice also show decreased liver TG accumulation; however, whether SCD...

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Bibliographic Details
Published in:Lipids Health Dis
Main Authors: Zhu, Xiaopeng, Yan, Hongmei, Xia, Mingfeng, Chang, Xinxia, Xu, Xi, Wang, Liu, Sun, Xiaoyang, Lu, Yan, Bian, Hua, Li, Xiaoying, Gao, Xin
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5952420/
https://ncbi.nlm.nih.gov/pubmed/29759071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12944-018-0762-0
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