Transcription factor 7-like 2 gene links increased in vivo insulin synthesis to type 2 diabetes

Transcription factor 7-like 2 (TCF7L2) is the main susceptibility gene for type 2 diabetes, primarily through impairing the insulin secretion by pancreatic β cells. However, the exact in vivo mechanisms remain poorly understood. We performed a family study and determined if the T risk allele of the...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Jainandunsing, Sjaam, Koole, H. Rita, van Miert, Joram N.I., Rietveld, Trinet, Wattimena, J.L. Darcos, Sijbrands, Eric J.G., de Rooij, Felix W.M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5952407/
https://ncbi.nlm.nih.gov/pubmed/29631902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.03.026
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