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Every enhancer works with every promoter for all the combinations tested: could new regulatory pathways evolve by enhancer shuffling?

The promoters and enhancers of cell type-specific genes are often conserved in evolution, and hence one might expect that a given enhancer has evolved to work best with its own promoter. While this expectation may be realized in some cases, we have not found evidence for it. A total of 27 combinatio...

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Vydáno v:Gene Expr
Hlavní autoři: Kermekchiev, Milko, Pettersson, Monica, Hamkalo, Barbara A., Schaffner, Walter
Médium: Artigo
Jazyk:Inglês
Vydáno: Cognizant Communication Corporation 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5952201/
https://ncbi.nlm.nih.gov/pubmed/1668145
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