Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles

Chronic infection by hepatitis B virus (HBV) is the major contributor to liver disease worldwide. Though HBV replicates via a nuclear episomal DNA (covalently closed circular DNA [cccDNA]), integration of HBV DNA into the host cell genome is regularly observed in the liver in infected patients. Whil...

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Sparad:
Bibliografiska uppgifter
I publikationen:J Virol
Huvudupphovsmän: Tu, Thomas, Budzinska, Magdalena A., Vondran, Florian W. R., Shackel, Nicholas A., Urban, Stephan
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2018
Ämnen:
Virus-Cell Interactions
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5952132/
https://ncbi.nlm.nih.gov/pubmed/29437961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02007-17
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