Metformin Mitigates Fibrosis and Glucose Intolerance Induced by Doxorubicin in Subcutaneous Adipose Tissue

Doxorubicin (DX) is a chemotherapeutic drug that is used in clinical practice that promotes deleterious side effects in non-tumor tissues such as adipose tissue. We showed that DX leads to extensive damage in adipose tissue via a disruption in 5′-adenosine monophosphate-activated protein kinase (AMP...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: Biondo, Luana A., Batatinha, Helena A., Souza, Camila O., Teixeira, Alexandre A. S., Silveira, Loreana S., Alonso-Vale, Maria I., Oyama, Lila M., Alves, Michele J., Seelaender, Marilia, Neto, José C. R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5952005/
https://ncbi.nlm.nih.gov/pubmed/29867463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00452
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