Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells

In contrast to mouse, human female germ cells develop asynchronously. Germ cells transition to meiosis, erase genomic imprints, and reactivate the X chromosome. It is unknown if these events all appear asynchronously, and how they relate to each other. Here we combine exome sequencing of human fetal...

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Vydáno v:Nat Commun
Hlavní autoři: Vértesy, Ábel, Arindrarto, Wibowo, Roost, Matthias S., Reinius, Björn, Torrens-Juaneda, Vanessa, Bialecka, Monika, Moustakas, Ioannis, Ariyurek, Yavuz, Kuijk, Ewart, Mei, Hailiang, Sandberg, Rickard, van Oudenaarden, Alexander, Chuva de Sousa Lopes, Susana M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951918/
https://ncbi.nlm.nih.gov/pubmed/29760424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04215-7
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