Aurora A-dependent CENP-A phosphorylation at inner centromeres protects bioriented chromosomes against cohesion fatigue

Sustained spindle tension applied to sister centromeres during mitosis eventually leads to uncoordinated loss of sister chromatid cohesion, a phenomenon known as “cohesion fatigue.” We report that Aurora A-dependent phosphorylation of serine 7 of the centromere histone variant CENP-A (p-CENP-AS7) pr...

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Argitaratua izan da:Nat Commun
Egile Nagusiak: Eot-Houllier, Grégory, Magnaghi-Jaulin, Laura, Fulcrand, Géraldine, Moyroud, François-Xavier, Monier, Solange, Jaulin, Christian
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951908/
https://ncbi.nlm.nih.gov/pubmed/29760389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04089-9
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