Treating a novel plasticity defect rescues episodic memory in Fragile X model mice

Episodic memory, a fundamental component of human cognition, is significantly impaired in autism. We report the first evidence for this problem in the Fmr1-knockout (KO) mouse model of Fragile X syndrome and describe potentially treatable underlying causes. The hippocampus is critical for the format...

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Bibliografiske detaljer
Udgivet i:Mol Psychiatry
Main Authors: Wang, Weisheng, Cox, Brittney M., Jia, Yousheng, Le, Aliza A., Cox, Conor D., Jung, Kwang M., Hou, Bowen, Piomelli, Daniele, Gall, Christine M., Lynch, Gary
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951717/
https://ncbi.nlm.nih.gov/pubmed/29133950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2017.221
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