Rapamycin-independent IGF2 expression in Tsc2-null mouse embryo fibroblasts and human lymphangioleiomyomatosis cells

Lymphangioleiomyomatosis (LAM) is a rare, almost exclusively female lung disease linked to inactivating mutations in tuberous sclerosis complex 2 (TSC2), a tumor suppressor gene that controls cell metabolic state and growth via regulation of the mechanistic target of rapamycin (mTORC1) signaling. mT...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Himes, Blanca E., Obraztsova, Kseniya, Lian, Lurong, Shumyatcher, Maya, Rue, Ryan, Atochina-Vasserman, Elena N., Hur, Stella K., Bartolomei, Marisa S., Evans, Jilly F., Krymskaya, Vera P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951544/
https://ncbi.nlm.nih.gov/pubmed/29758070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197105
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