Phase I Study of a Novel Oral Janus Kinase 2 Inhibitor, SB1518, in Patients With Relapsed Lymphoma: Evidence of Clinical and Biologic Activity in Multiple Lymphoma Subtypes

PURPOSE: The Janus kinase 2/signal transducers and activators of transcription (JAK2/STAT) pathway plays an important role in the pathogenesis of hematologic malignancies. We conducted a phase I dose-finding and pharmacokinetic/pharmacodynamic study of SB1518, a potent JAK2 inhibitor, in patients wi...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Younes, Anas, Romaguera, Jorge, Fanale, Michelle, McLaughlin, Peter, Hagemeister, Frederick, Copeland, Amanda, Neelapu, Sattva, Kwak, Larry, Shah, Jatin, de Castro Faria, Silvana, Hart, Stefan, Wood, Jeanette, Jayaraman, Ramesh, Ethirajulu, Kantharaj, Zhu, Joy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2012
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ORIGINAL REPORTS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5950499/
https://ncbi.nlm.nih.gov/pubmed/22965964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2012.42.5223
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