Gain-of-function mutations in granulocyte colony–stimulating factor receptor (CSF3R) reveal distinct mechanisms of CSF3R activation

Granulocyte colony–stimulating factor (G-CSF or CSF3) and its receptor CSF3R regulate granulopoiesis, neutrophil function, and hematopoietic stem cell mobilization. Recent studies have uncovered an oncogenic role of mutations in the CSF3R gene in many hematologic malignancies. To find additional CSF...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zhang, Haijiao, Coblentz, Cody, Watanabe-Smith, Kevin, Means, Sophie, Means, Jasmine, Maxson, Julia E., Tyner, Jeffrey W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5950016/
https://ncbi.nlm.nih.gov/pubmed/29572350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002417
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