Kinetics and structural features of dimeric glutamine-dependent bacterial NAD(+) synthetases suggest evolutionary adaptation to available metabolites

NADH (NAD(+)) and its reduced form NADH serve as cofactors for a variety of oxidoreductases that participate in many metabolic pathways. NAD(+) also is used as substrate by ADP-ribosyl transferases and by sirtuins. NAD(+) biosynthesis is one of the most fundamental biochemical pathways in nature, an...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Santos, Adrian Richard Schenberger, Gerhardt, Edileusa Cristina Marques, Moure, Vivian Rotuno, Pedrosa, Fábio Oliveira, Souza, Emanuel Maltempi, Diamanti, Riccardo, Högbom, Martin, Huergo, Luciano Fernandes
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5950007/
https://ncbi.nlm.nih.gov/pubmed/29581233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002241
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