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Guanylate cyclase–activating protein 2 contributes to phototransduction and light adaptation in mouse cone photoreceptors

Light adaptation of photoreceptor cells is mediated by Ca(2+)-dependent mechanisms. In darkness, Ca(2+) influx through cGMP-gated channels into the outer segment of photoreceptors is balanced by Ca(2+) extrusion via Na(+)/Ca(2+), K(+) exchangers (NCKXs). Light activates a G protein signaling cascade...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Vinberg, Frans, Peshenko, Igor V., Chen, Jeannie, Dizhoor, Alexander M., Kefalov, Vladimir J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949989/
https://ncbi.nlm.nih.gov/pubmed/29549122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001574
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