Reduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL/6 mice

Dry Eye disease causes discomfort and pain in millions of patients. Using a mouse acute desiccating stress (DS) model we show that DS induces a reduction in intraepithelial corneal nerve (ICN) density, corneal sensitivity, and apical extension of the intraepithelial nerve terminals (INTs) that branc...

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Detalhes bibliográficos
Publicado no:Exp Eye Res
Main Authors: Stepp, Mary Ann, Pal-Ghosh, Sonali, Tadvalkar, Gauri, Williams, Alexa, Pflugfelder, Stephen C., de Paiva, Cintia S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949876/
https://ncbi.nlm.nih.gov/pubmed/29407221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2018.01.024
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