Discovery and Development of 8-Substituted Cycloberberine Derivatives as Novel Antibacterial Agents against MRSA

[Image: see text] 8-Acetoxycycloberberine (2) with a unique skeleton was first identified to display a potent activity profile against Gram-positive bacteria, especially methicillin-resistant S. aureus (MRSA) with minimum inhibitory concentration (MIC) values of 1–8 μg/mL, suggesting a possible nove...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Fan, Tianyun, Hu, Xinxin, Tang, Sheng, Liu, Xiaojia, Wang, Yanxiang, Deng, Hongbin, You, Xuefu, Jiang, Jiandong, Li, Yinghong, Song, Danqing
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2018
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949831/
https://ncbi.nlm.nih.gov/pubmed/29795764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00094
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