Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia

[Image: see text] Metabolic reprogramming of cancer cells is essential for tumorigenesis in which pyruvate kinase M2 (PKM2), the low activity isoform of pyruvate kinase, plays a critical role. Herein, we describe the identification of a nature-product-derived micheliolide (MCL) that selectively acti...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Li, Jing, Li, Shanshan, Guo, Jianshuang, Li, Qiuying, Long, Jing, Ma, Cheng, Ding, Yahui, Yan, Chunli, Li, Liangwei, Wu, Zhigang, Zhu, He, Li, Keqin Kathy, Wen, Liuqing, Zhang, Quan, Xue, Qingqing, Zhao, Caili, Liu, Ning, Ivanov, Ivaylo, Luo, Ming, Xi, Rimo, Long, Haibo, Wang, Peng George, Chen, Yue
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949721/
https://ncbi.nlm.nih.gov/pubmed/29641204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00241
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