Downregulation of Leucine-Rich Repeat-Containing 8A Limits Proliferation and Increases Sensitivity of Glioblastoma to Temozolomide and Carmustine

BACKGROUND: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Ubiquitously expressed volume-regulated anion channels (VRAC) are thought to play a role in cell proliferation, migration, and apoptosis. VRAC are heteromeric channel complexes assembled from proteins belongin...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Rubino, Sebastian, Bach, Martin D., Schober, Alexandra L., Lambert, Ian H., Mongin, Alexander A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949383/
https://ncbi.nlm.nih.gov/pubmed/29868469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00142
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