Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid

Hepatocellular carcinoma (HCC) is a highly lethal cancer that has a high rate of recurrence, in part because of cancer stem cell (CSC)-dependent field cancerization. Acyclic retinoid (ACR) is a synthetic vitamin A-like compound capable of preventing the recurrence of HCC. Here, we performed a genome...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Qin, Xian-Yang, Suzuki, Harukazu, Honda, Masao, Okada, Hikari, Kaneko, Shuichi, Inoue, Ikuyo, Ebisui, Etsuko, Hashimoto, Kosuke, Carninci, Piero, Kanki, Keita, Tatsukawa, Hideki, Ishibashi, Naoto, Masaki, Takahiro, Matsuura, Tomokazu, Kagechika, Hiroyuki, Toriguchi, Kan, Hatano, Etsuro, Shirakami, Yohei, Shiota, Goshi, Shimizu, Masahito, Moriwaki, Hisataka, Kojima, Soichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949003/
https://ncbi.nlm.nih.gov/pubmed/29686061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1802279115
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