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Lifetime of muscarinic receptor–G-protein complexes determines coupling efficiency and G-protein subtype selectivity

G-protein–coupled receptors (GPCRs) are essential for the detection of extracellular stimuli by cells and transfer the encoded information via the activation of functionally distinct subsets of heterotrimeric G proteins into intracellular signals. Despite enormous achievements toward understanding G...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Ilyaskina, Olga S., Lemoine, Horst, Bünemann, Moritz
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948956/
https://ncbi.nlm.nih.gov/pubmed/29686069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715751115
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