Homologous recombination occurs frequently at innate GT microsatellites in normal somatic and germ cells in vivo

BACKGROUND: In somatic cells, homologous recombination (HR) is a rare event caused by eventual DNA double-strand breaks (DSBs). In contrast, germ cells show high frequency of HR caused by programmed DSBs. Microsatellites are prone to DSBs during genome replication and, thereby, capable of promoting...

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Библиографические подробности
Опубликовано в: :BMC Genomics
Главные авторы: Zheng, Jianbo, Li, Heng, Zhang, Qi, Sun, Lei, Liu, Xiangfang, Luo, Chen
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2018
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948810/
https://ncbi.nlm.nih.gov/pubmed/29751739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-018-4758-y
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