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Efficacy and Safety of Glycosidic Enzymes for Improved Gene Delivery to the Retina following Intravitreal Injection in Mice

Viral gene delivery is showing great promise for treating retinal disease. Although subretinal vector delivery has mainly been used to date, intravitreal delivery has potential advantages if low retinal transduction efficiency can be overcome. To this end, we investigated the effects of co-injection...

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Détails bibliographiques
Publié dans:Mol Ther Methods Clin Dev
Auteurs principaux: Cehajic-Kapetanovic, Jasmina, Milosavljevic, Nina, Bedford, Robert A., Lucas, Robert J., Bishop, Paul N.
Format: Artigo
Langue:Inglês
Publié: American Society of Gene & Cell Therapy 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948313/
https://ncbi.nlm.nih.gov/pubmed/29766027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.12.002
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