Targeting MUC1-C suppresses BCL2A1 in triple-negative breast cancer

B-cell lymphoma 2-related protein A1 (BCL2A1) is a member of the BCL-2 family of anti-apoptotic proteins that confers resistance to treatment with anti-cancer drugs; however, there are presently no agents that target BCL2A1. The MUC1-C oncoprotein is aberrantly expressed in triple-negative breast ca...

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Pubblicato in:Signal Transduct Target Ther
Autori principali: Hiraki, Masayuki, Maeda, Takahiro, Mehrotra, Neha, Jin, Caining, Alam, Maroof, Bouillez, Audrey, Hata, Tsuyoshi, Tagde, Ashujit, Keating, Amy, Kharbanda, Surender, Singh, Harpal, Kufe, Donald
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948210/
https://ncbi.nlm.nih.gov/pubmed/29760958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-018-0013-x
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