Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive

Major Depressive Disorder (MDD) is considered a “circuitopathy”, and brain stimulation therapies hold promise for ameliorating MDD symptoms, including hippocampal dysfunction. It is unknown if stimulation of upstream hippocampal circuitry, such as the entorhinal cortex (Ent), is antidepressive, alth...

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Foilsithe in:Nat Med
Main Authors: Yun, Sanghee, Reynolds, Ryan P., Petrof, Iraklis, White, Alicia, Rivera, Phillip D., Segev, Amir, Gibson, Adam D., Suarez, Maiko, Desalle, Matthew J., Ito, Naoki, Mukherjee, Shibani, Richardson, Devon R., Kang, Catherine E., Ahrens-Nicklas, Rebecca C., Soler, Ivan, Chetkovich, Dane M., Kourrich, Saïd, Coulter, Douglas A., Eisch, Amelia J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948139/
https://ncbi.nlm.nih.gov/pubmed/29662202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0002-1
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