Autophagy mediates tumor necrosis factor-α-induced phenotype switching in vascular smooth muscle A7r5 cell line

Vascular smooth muscle cells (VSMC) dedifferentiation from a contractile to a synthetic phenotype contributes to atherosclerosis. Atherosclerotic tissue has a chronic inflammatory component with high levels of tumor necrosis factor-α (TNF-α). VSMC of atheromatous plaques have increased autophagy, a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: García-Miguel, Marina, Riquelme, Jaime A., Norambuena-Soto, Ignacio, Morales, Pablo E., Sanhueza-Olivares, Fernanda, Nuñez-Soto, Constanza, Mondaca-Ruff, David, Cancino-Arenas, Nicole, San Martín, Alejandra, Chiong, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5947899/
https://ncbi.nlm.nih.gov/pubmed/29750813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197210
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