Relative Bioavailability, Intranasal Abuse Potential, and Safety of Benzhydrocodone/Acetaminophen Compared with Hydrocodone Bitartrate/Acetaminophen in Recreational Drug Abusers

OBJECTIVES: Benzhydrocodone is a hydrocodone prodrug that has been combined with acetaminophen (APAP) in a novel immediate-release analgesic. This study evaluated the relative bioavailability, intranasal abuse potential, and safety of benzhydrocodone/APAP compared with commercially available hydroco...

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Опубликовано в: :Pain Med
Главные авторы: Guenther, Sven M, Mickle, Travis C, Barrett, Andrew C, Roupe, Kathryn Ann, Zhou, Jing, Lam, Vincent
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2018
Предметы:
OPIOIDS & SUBSTANCE USE DISORDERS SECTION
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946936/
https://ncbi.nlm.nih.gov/pubmed/29025138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/pm/pnx195
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