Stendomycin selectively inhibits tIM23-dependent mitochondrial protein import

Tim17 and Tim23 are the main subunits of the TIM23 complex, one of the two major essential mitochondrial inner-membrane protein translocon machineries (TIMs). No chemical probes that specifically inhibit TIM23-dependent protein import were known to exist. Here we show that the natural product stendo...

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Pubblicato in:Nat Chem Biol
Autori principali: Filipuzzi, Ireos, Steffen, Janos, Germain, Mitchel, Goepfert, Laetitia, Conti, Michael A, Potting, Christoph, Cerino, Raffaele, Pfeifer, Martin, Krastel, Philipp, Hoepfner, Dominic, Bastien, Julie, Koehler, Carla M, Helliwell, Stephen B
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945950/
https://ncbi.nlm.nih.gov/pubmed/28991239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2493
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