Cloning and Transcriptional Activity Analysis of the Porcine Abcb1 Gene Promoter: Transcription Factor Sp1 Regulates the Expression of Porcine Abcb1

P-Glycoprotein (P-gp, Abcb1) plays a crucial role in drug disposition and functions by hydrolyzing ATP. However, little is known about the regulatory elements governing the transcription of the porcine Abcb1 gene. In this study, the transcription start site of the pig Abcb1 gene was identified by 5′...

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Publicado en:Front Pharmacol
Autores principales: Guo, Tingting, Huang, Jinhu, Huan, Changchao, He, Fang, Zhang, Yujuan, Bhutto, Zohaib A., Wang, Liping
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945876/
https://ncbi.nlm.nih.gov/pubmed/29780320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00373
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