The LuxS/AI-2 Quorum-Sensing System of Streptococcus pneumoniae Is Required to Cause Disease, and to Regulate Virulence- and Metabolism-Related Genes in a Rat Model of Middle Ear Infection

Objective: Streptococcus pneumoniae colonizes the nasopharynx of children, and from nasopharynx it could migrate to the middle ear and causes acute otitis media (AOM). During colonization and AOM, the pneumococcus forms biofilms. In vitro biofilm formation requires a functional LuxS/AI-2 quorum-sens...

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Detalhes bibliográficos
Publicado no:Front Cell Infect Microbiol
Main Authors: Yadav, Mukesh K., Vidal, Jorge E., Go, Yoon Y., Kim, Shin H., Chae, Sung-Won, Song, Jae-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945837/
https://ncbi.nlm.nih.gov/pubmed/29780750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2018.00138
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