Semaphorin 4D correlates with increased bone resorption, hypercalcemia, and disease stage in newly diagnosed patients with multiple myeloma

Multiple myeloma (MM) is characterized by bone destruction due to increased bone resorption and decreased bone formation. Semaphorin 4D (CD100, Sema4D) is expressed by osteoclasts, binds to its receptor Plexin-B1, and acts as a mediator of osteoclast–osteoblast interaction that ultimately inhibits o...

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Detalhes bibliográficos
Publicado no:Blood Cancer J
Main Authors: Terpos, Evangelos, Ntanasis-Stathopoulos, Ioannis, Christoulas, Dimitrios, Bagratuni, Tina, Bakogeorgos, Marios, Gavriatopoulou, Maria, Eleutherakis-Papaiakovou, Evangelos, Kanellias, Nikolaos, Kastritis, Efstathios, Dimopoulos, Meletios A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945651/
https://ncbi.nlm.nih.gov/pubmed/29748532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41408-018-0075-6
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