Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells

Glioblastoma multiforme is a brain malignancy characterized by high heterogeneity, invasiveness, and resistance to current therapies, attributes related to the occurrence of glioma stem cells (GSCs). Transforming growth factor β (TGFβ) promotes self-renewal and bone morphogenetic protein (BMP) induc...

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Veröffentlicht in:Oncogene
Hauptverfasser: Caja, Laia, Tzavlaki, Kalliopi, Dadras, Mahsa S., Tan, E-Jean, Hatem, Gad, Maturi, Naga P., Morén, Anita, Wik, Lotta, Watanabe, Yukihide, Savary, Katia, Kamali-Moghaddan, Masood, Uhrbom, Lene, Heldin, Carl-Henrik, Moustakas, Aristidis
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945579/
https://ncbi.nlm.nih.gov/pubmed/29449696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0136-0
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