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Use of a Cholesterol Recognition Amino Acid Consensus Peptide To Inhibit Binding of a Bacterial Toxin to Cholesterol

Recognition of and binding to cholesterol on the host cell membrane is an initial step in the mechanism of numerous pathogens, including viruses, bacteria, and bacterial toxins; however, a viable method of inhibiting this interaction has not yet been uncovered. Here, we describe the mechanism by whi...

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Pubblicato in:Biochemistry
Autori principali: Koufos, Evan, Chang, En Hyung, Rasti, Elnaz S., Krueger, Eric, Brown, Angela C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945288/
https://ncbi.nlm.nih.gov/pubmed/27504950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00430
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