Blockade of the swelling-induced chloride current attenuates the mouse neonatal hypoxic-ischemic brain injury in vivo

Activation of swelling-induced Cl(−) current (I(Cl,swell)) during neonatal hypoxia-ischemia (HI) may induce brain damage. Hypoxic-ischemic brain injury causes chronic neurological morbidity in neonates as well as acute mortality. In this study, we investigated the role of I(Cl,swell) in hypoxic-isch...

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Bibliografske podrobnosti
izdano v:Acta Pharmacol Sin
Main Authors: Wong, Raymond, Abussaud, Ahmed, Leung, Joseph WH, Xu, Bao-feng, Li, Fei-ya, Huang, Sammen, Chen, Nai-hong, Wang, Guan-lei, Feng, Zhong-ping, Sun, Hong-shuo
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943910/
https://ncbi.nlm.nih.gov/pubmed/29595192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2018.1
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