The tyrosine-kinase inhibitor sunitinib targets vascular endothelial (VE)-cadherin: a marker of response to antitumoural treatment in metastatic renal cell carcinoma

BACKGROUND: Vascular endothelial (VE)-cadherin is an endothelial cell-specific protein responsible for endothelium integrity. Its adhesive properties are regulated by post-translational processing, such as tyrosine phosphorylation at site Y(685) in its cytoplasmic domain, and cleavage of its extrace...

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Published in:Br J Cancer
Main Authors: Polena, Helena, Creuzet, Julie, Dufies, Maeva, Sidibé, Adama, Khalil-Mgharbel, Abir, Salomon, Aude, Deroux, Alban, Quesada, Jean-Louis, Roelants, Caroline, Filhol, Odile, Cochet, Claude, Blanc, Ellen, Ferlay-Segura, Céline, Borchiellini, Delphine, Ferrero, Jean-Marc, Escudier, Bernard, Négrier, Sylvie, Pages, Gilles, Vilgrain, Isabelle
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943344/
https://ncbi.nlm.nih.gov/pubmed/29563634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0054-5
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