Study protocol for the G-SPIRIT trial: a randomised, placebo-controlled, double-blinded phase III trial of granulocyte colony-stimulating factor-mediated neuroprotection for acute spinal cord injury

INTRODUCTION: Granulocyte colony-stimulating factor (G-CSF) is generally used for neutropaenia. Previous experimental studies revealed that G-CSF promoted neurological recovery after spinal cord injury (SCI). Next, we moved to early phase of clinical trials. In a phase I/IIa trial, no adverse events...

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Pubblicato in:BMJ Open
Autori principali: Koda, Masao, Hanaoka, Hideki, Sato, Takatoshi, Fujii, Yasuhisa, Hanawa, Michiko, Takahashi, Sho, Furuya, Takeo, Ijima, Yasushi, Saito, Junya, Kitamura, Mitsuhiro, Ohtori, Seiji, Matsumoto, Yukei, Abe, Tetsuya, Watanabe, Kei, Hirano, Toru, Ohashi, Masayuki, Shoji, Hirokazu, Mizouchi, Tatsuki, Takahashi, Ikuko, Kawahara, Norio, Kawaguchi, Masahito, Orita, Yugo, Sasamoto, Takeshi, Yoshioka, Masahito, Fujii, Masafumi, Yonezawa, Katsutaka, Soma, Daisuke, Taneichi, Hiroshi, Takeuchi, Daisaku, Inami, Satoshi, Moridaira, Hiroshi, Ueda, Haruki, Asano, Futoshi, Shibao, Yosuke, Aita, Ikuo, Takeuchi, Yosuke, Mimura, Masaya, Shimbo, Jun, Someya, Yukio, Ikenoue, Sumio, Sameda, Hiroaki, Takase, Kan, Ikeda, Yoshikazu, Nakajima, Fumitake, Hashimoto, Mitsuhiro, Ozawa, Tomoyuki, Hasue, Fumio, Fujiyoshi, Takayuki, Kamiya, Koshiro, Watanabe, Masahiko, Katoh, Hiroyuki, Matsuyama, Yukihiro, Yamamoto, Yu, Togawa, Daisuke, Hasegawa, Tomohiko, Kobayashi, Sho, Yoshida, Go, Oe, Shin, Banno, Tomohiro, Arima, Hideyuki, Akeda, Koji, Kawamoto, Eiji, Imai, Hiroshi, Sakakibara, Toshihiko, Sudo, Akihiro, Ito, Yasuo, Kikuchi, Tsuyoshi, Osaki, Shuhei, Tanaka, Nobuhiro, Nakanishi, Kazuyoshi, Kamei, Naosuke, Kotaka, Shinji, Baba, Hideo, Okudaira, Tsuyoshi, Konishi, Hiroaki, Yamaguchi, Takayuki, Ito, Keigo, Katayama, Yoshito, Matsumoto, Taro, Matsumoto, Tomohiro, Idota, Masaru, Kanno, Haruo, Aizawa, Toshimi, Hashimoto, Ko, Eto, Toshimitsu, Sugaya, Takehiro, Matsuda, Michiharu, Fushimi, Kazunari, Nozawa, Satoshi, Iwai, Chizuo, Taguchi, Toshihiko, Kanchiku, Tsukasa, Suzuki, Hidenori, Nishida, Norihiro, Funaba, Masahiro, Yamazaki, Masashi
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2018
Soggetti:
Neurology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5942478/
https://ncbi.nlm.nih.gov/pubmed/29730616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2017-019083
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