Activity of a novel protonophore against methicillin-resistant Staphylococcus aureus

AIM: Compound 1-(4-chlorophenyl)-4,4,4-trifluoro-3-hydroxy-2-buten-1-one (compound 1) was identified as a hit against methicillin-resistant Staphylococcus aureus (MRSA) strain MW2. METHODS & RESULTS: The MIC of compound 1 against MRSA was 4 μg/ml. The compound showed enhanced activity at acidic...

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Pubblicato in:Future Med Chem
Autori principali: Tharmalingam, Nagendran, Jayamani, Elamparithi, Rajamuthiah, Rajmohan, Castillo, Dawilmer, Fuchs, Beth Burgwyn, Kelso, Michael J, Mylonakis, Eleftherios
Natura: Artigo
Lingua:Inglês
Pubblicazione: Future Science Ltd 2017
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5941710/
https://ncbi.nlm.nih.gov/pubmed/28771026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc-2017-0047
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