Afterload Promotes Maturation of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes in Engineered Heart Tissues

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) grown in engineered heart tissue (EHT) can be used for drug screening, disease modeling, and heart repair. However, the immaturity of hiPSC-CMs currently limits their use. Because mechanical loading increases during development an...

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Vydáno v:J Mol Cell Cardiol
Hlavní autoři: Leonard, Andrea, Bertero, Alessandro, Powers, Joseph D., Beussman, Kevin M., Bhandari, Shiv, Regnier, Michael, Murry, Charles E., Sniadecki, Nathan J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940558/
https://ncbi.nlm.nih.gov/pubmed/29604261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2018.03.016
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