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The carbon chain-selective adenylation enzyme TamA: the missing link between fatty acid and pyrrole natural product biosynthesis

The marine bacterium Pseudoalteromonas tunicata produces the bipyrrole antibiotic tambjamine YP1. This natural product is built from common amino acid and fatty acid building blocks in a biosynthetic pathway that is encoded in the tam operon which contains 19 genes. The exact role that each of these...

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Detalhes bibliográficos
Publicado no:Org Biomol Chem
Main Authors: Marchetti, Piera M., Kelly, Van, Simpson, Joanna P., Ward, Mairi, Campopiano, Dominic J.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5939613/
https://ncbi.nlm.nih.gov/pubmed/29594310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8ob00441b
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