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Developmentally inspired programming of adult human mesenchymal stromal cells toward stable chondrogenesis

It is generally accepted that adult human bone marrow-derived mesenchymal stromal cells (hMSCs) are default committed toward osteogenesis. Even when induced to chondrogenesis, hMSCs typically form hypertrophic cartilage that undergoes endochondral ossification. Because embryonic mesenchyme is obviou...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Occhetta, Paola, Pigeot, Sebastien, Rasponi, Marco, Dasen, Boris, Mehrkens, Arne, Ullrich, Thomas, Kramer, Ina, Guth-Gundel, Sabine, Barbero, Andrea, Martin, Ivan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5939088/
https://ncbi.nlm.nih.gov/pubmed/29666250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720658115
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