Role of PD-1 during effector CD8 T cell differentiation

PD-1 (programmed cell death-1) is the central inhibitory receptor regulating CD8 T cell exhaustion during chronic viral infection and cancer. Interestingly, PD-1 is also expressed transiently by activated CD8 T cells during acute viral infection, but the role of PD-1 in modulating T cell effector di...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Ahn, Eunseon, Araki, Koichi, Hashimoto, Masao, Li, Weiyan, Riley, James L., Cheung, Jeanne, Sharpe, Arlene H., Freeman, Gordon J., Irving, Bryan A., Ahmed, Rafi
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5939075/
https://ncbi.nlm.nih.gov/pubmed/29654146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718217115
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