DRUG-NEM: Optimizing drug combinations using single-cell perturbation response to account for intratumoral heterogeneity

An individual malignant tumor is composed of a heterogeneous collection of single cells with distinct molecular and phenotypic features, a phenomenon termed intratumoral heterogeneity. Intratumoral heterogeneity poses challenges for cancer treatment, motivating the need for combination therapies. Si...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Anchang, Benedict, Davis, Kara L., Fienberg, Harris G., Williamson, Brian D., Bendall, Sean C., Karacosta, Loukia G., Tibshirani, Robert, Nolan, Garry P., Plevritis, Sylvia K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5939057/
https://ncbi.nlm.nih.gov/pubmed/29654148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711365115
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados