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DRUG-NEM: Optimizing drug combinations using single-cell perturbation response to account for intratumoral heterogeneity
An individual malignant tumor is composed of a heterogeneous collection of single cells with distinct molecular and phenotypic features, a phenomenon termed intratumoral heterogeneity. Intratumoral heterogeneity poses challenges for cancer treatment, motivating the need for combination therapies. Si...
Tallennettuna:
| Julkaisussa: | Proc Natl Acad Sci U S A |
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| Päätekijät: | , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5939057/ https://ncbi.nlm.nih.gov/pubmed/29654148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711365115 |
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